View research view latest news sign up for updates. Granular cell tumor of the tongue dilde granuler hucreli tumor alper kanmaz1, yunus feyyat sakin2, togay muderris1, nazm bozan3, muzaffer kr. Since this generally benign tumor may be misdiagnosed as malignant in clinical investigation, mammography, sonography, and even in frozen sections, a preoperative diagnosis is of utmost importance. All structured data from the file and property namespaces is available under the creative commons cc0 license. In 1931, abrikossoff described the first case of granular cell tumor gct in the esophagus. Pdf download an 82yearold woman with atrial fibrillation and chronic obstructive pulmonary disease presented with pruritic and painful lesions on the tongue of 10 years duration. Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time it is also known as abrikossoffs tumor, granular cell myoblastoma, granular cell nerve sheath tumor, and granular cell schwannoma. Gct was described in 1926 by abrikossoff and the etiology of this disease is controversial and much discussed in the literature. Read histogenesis of abrikossoff tumour of the oral cavity, international journal of dental hygiene on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Abrikossoffs tumor is a disease that more commonly affects the oral cavity but can also occur at other sites. Summary the granular cell tumor get represents a rare but important lesion in the differential diagnosis of breast tumors.
Granular cell tumors gcts are a type of submucosal tumor, with an overall soft tissue tumor incidence of 0. Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time it is also known as abrikossoff s tumor, granular cell myoblastoma, granular cell nerve sheath tumor, and granular cell schwannoma. The histogenesis of granular cell tumors is unknown. Diagnostic difficulties may arise because histopathological features of the. Oct 21, 20 granular cell tumors gct, especially in the esophagus, are rare neoplasms originating from the nervous system. Abrikossoffs tumor of the vulva, case report and literature.
It occurs usually in the neck region or in the head. It is difficult to distinguish granular cell tumor from other subepithelial tumors. Mitochondriarich epithelioid leiomyoma of the ciliary. Abrikossoffs tumor or granular cell tumor gct is usually benign. Granular cell tumor of anal border journal of coloproctology. Leiomyoma is a rare benign, smooth musclederived tumor that can arise from all parts of the uveal tract. A 55yearold man with a nodular lesion on the left arm resorted to surgery consultation. The patient underwent a surgical tumorectomy and inguinal lymph nodes resection. A primeira descricao deste tumor foi em 1926 por abrikossoff.
We confirmed the diagnosis using histological and immunohistochemical examinations. Granular cell tumors gct are relatively infrequent lesions that were initially described by abrikossoff in 1926 as part of a series of five tumors of the tongue, which he called myoblastoma. Granular cell tumor is a rare benign tumor that can present a pseudoepitheliomatous hyperplasia of the covering epithelium. Granular cell tumors or abrikossoff tumors are rare and usually benign tumors. Endoscopic and eus images of esophageal granular cell tumors. The tumor is composed of polygonal cells, with abundant eosinophilic granular cytoplasm. Granular cell or abrikossoffs tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Adjuvant radiation therapy for malignant abrikossoffs.
Download pdf abstract the lesion of congenital granular cells, also known as neumann tumor or congenital epulide tumor, is a benign and rare congenital lesion, with incidence in newborns with predilection by the female gender and occurs predominantly in the anterior alveolar ridge of the maxilla. Most common locations are the head and neck, with only a few cases reported on the upper limbs. Granular cell tumor gct, a relatively rare neuroectodermal tumor occurring most often in the head and neck region, is not uncommonly associated with pseudoepitheliomatous hyperplasia of the overlying surface epithelium, which may be at times nonreadily distinguishable from welldifferentiated squamous cell carcinoma scc. We report a case of a 43yearsold patient who had a benign abrikossoffs tumor localized in the right femoral triangle diagnosed at the biopsy. When they are located in the breast, physical examination, mammographic, ultrasonographic findings. More than half of the head and neck lesions are localized to the oral cavity, especially the tongue. Granular cell tumor abrikossoff tumor of the thyroid gland.
We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. It might involve multiple anatomical sites, most frequently the head and neck. Sep 17, 2015 granular cell tumors gcts were firstly described by weber in 1854 and 70 years later by abrikossoff and classified as benign tumors. Surgical management of granular cell tumor of the orbit. Abrikossoffs tumor or granular cell tumor is a rare soft and usually benign tissue neoplasm of neural origin. We present the case of a 65yearold male patient, who was admitted to our hospital for an. Coexistent squamous cell carcinoma and granular cell tumor. The esophageal involvement was rarely described 2% of cases. Pdf granular cell tumor gct, also known as abrikossoffs tumor, is a relatively.
Granular cell tumor gct also known as abrikossoffs tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. Gcts are uncommon tumors and they may arise in any part of the body. Granular cell tumor is an uncommon neoplasm that can occur in any part of the body, including the orofacial region. We report a very rare case of granular cell tumor with a center ulcer of the rectum, which was detected in a 47yearold man during screening colonoscopy. While the tumor can be seen in all parts of the body it is generally located on the head and neck region, and especially on the tongue. Granular cell tumor in differential diagnosis of tumors of. Neoplastic cells characteristically dissect the collagen fibers hematoxylin and eosin stain, original magnification. Abrikossoff s tumor is a disease that more commonly affects the oral cavity but can also occur at other sites.
Granular cell tumor gct is a rare neoplasm of the soft tissues, and abrikossoff described the first case of granular cell tumor gct in the esophagus. Some malignant cases have been reported in literature. The most widely accepted hypothesis is that granular cell tumor arises from the altered metabolism of schwann cells. A granular cell tumor is one of the rare tumors of the esophagus. The aim of this study was to report one granular cells tumor of the cervical. Granular cell tumor gct also known as abrikossoff s tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. Abrikossoffs tumours, or granular cell tumours gcts, are uncommon, usually benign, neoplasms that are thought to derive from schwann cells of the peripheral nerves. Granular cell tumor, also known as granular cell myoblastoma or abrikossoff s tumor, is a rare tumor of unknown etiology that more commonly affects the oral cavity but can also occur at other sites. The tumor is usually benign, but there are reports of cases in which the tumor shows a locally aggressive behavior, malignancy, and distant metastases. They can originate anywhere in the body but are most frequently found in the head and neck, particularly in the oral cavity. It develops between the second and sixth decades of life, more frequently among women.
This feature can possibly be misunderstood with squamous cell carcinoma. Granular cell tumor gct was first described by abrikossoff in 1926. Pruritic and painful nodules on the tongue mdedge dermatology. Diagnosis is histological and treatment controversial. This lesion is not encapsulated and can be characterized by a pseudo invasive growth pattern, represented by the tumoral cells that infiltrate between adjacent connective tissue elements. Granular cell tumour gct, abrikossoffs tumour at or myoblastoma my is a rather.
Abrikossoffs tumor or granular cell tumor is an infrequent benign neoplasm, first described by the russian pathologist abrikossoff in 1926. Nodule was firm, mobile, painless and nonulcerated. Granular cell tumors gcts, previously called granular cell myoblastomas or abrikossoffs tumors, are uncommon neoplasms first described in the tongue by abrikossoff in 1926. Sox10 and s100 in the diagnosis of softtissue neoplasms. She had not undergone treatment with systemic or inhaled corticosteroids during the course of the pulmonary disease. Granular cell tumor gct, also known as abrikossoffs tumor or granular cell myoblastoma, is a rare benign neoplasm of soft tissues, characterized by the accumulation of plump cells with abundant granular cytoplasm 1, 2. Abrikossoff s tumor or granular cell tumor is an infrequent benign neoplasm, first described by the russian pathologist abrikossoff in 1926. Volume 32, issue 4, octoberdecember 2019, pages 145147. Mitochondriarich epithelioid leiomyoma of the ciliary body. Oral granular cell tumor is a benign oral disease of possible neural origin commonly located on the tongue. Feb 01, 2010 read histogenesis of abrikossoff tumour of the oral cavity, international journal of dental hygiene on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Springer nature is making sarscov2 and covid19 research free. Granular cell tumor, also known as abrikossoff tumor, is a rare infrequent neoplasm of unclear etiology which has been rarely described in children. There is still some controversy regarding the diagnosis and treatment of esophageal gct.
Granular cell tumor was described first by abrikossoff in 1926. Fewer than 30 leiomyomas of the ciliary body have been reported, but often these. Abrikossoffs tumor is a disease that more commonly affects the oral cavity but can also occur at. Total excision using a limberg flap procedure was performed. Post graduate student of the oral pathology program, school of. Novel diagnosis and treatment of esophageal granular cell. Metachronous abrikossoffs tumour of the breast and tongue. Gct is a rarely seen soft tissue tumor and is generally benign.
Benign tumors and tumorlike proliferations tumors of the. Becelli r1, perugini m, gasparini g, cassoni a, fabiani f. Granular cell tumors gcts were firstly described by weber in 1854 and 70 years later by abrikossoff and classified as benign tumors. Granular cell myoblastoma abrikossoff tumor of the chest. Computed tomography and magnetic resonance imaging findings of intraorbital granular cell tumor abrikossoff s tumor. They are benign neural tumors presenting typically in the dermis or subcutis, in adults, and more frequently in women. Originally considered muscle tumors, they have been identified as neural lesions, due to their close association with nerve and to their immunohystochemical characteristics. The neural histogenetic origin of the oral granular cell. Abrikossoffs tumour or granular cell tumour is a rare entity. Aa a whitetogray tumor with a smooth surface and ab the eus image of the same patient showing hypoechoic, homogeneous, smoothedged lesions derived from mucosal layers.
If you need to print pages from this book, we recommend downloading it as a pdf. Unfortunately, this book cant be printed from the openbook. Granular cell tumor abrikossoff tumor of the thyroid. The neural histogenetic origin of the oral granular cell tumor. Epulis eines neugeborenen histogenetischer vergleich zum. A case report of a rare intramuscular granular cell tumor. The neoplasm can affect all parts of the body with head and neck areas affected in 4565% of patients. However, our case had a center ulcer unlike previous cases. Abrikossoff tumor or granular cell tumor usually present as unencapsulated, small.
Files are available under licenses specified on their description page. Pdf granular cell tumor of the tongue abrikossoffs tumor. A rare granular cell tumor with a center ulcer of the rectum. Granular cell tumor mimicking a squamous cell carcinoma of.
Jun 20, 2018 granular cell or abrikossoffs tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Histologically these tumors are characterized by large eosinophilic granular cells, similar to granular cell tumors in adults which are often seen as abrikossoff. Histogenesis of abrikossoff tumour of the oral cavity. Mar 19, 2010 granular cell tumor, also known as granular cell myoblastoma or abrikossoffs tumor, is a rare tumor of unknown etiology that more commonly affects the oral cavity but can also occur at other sites.
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