Terminology, differences, and similarities article pdf available in soft matter 86. Microemulsion definition is an emulsion in which the dispersed phase is in the form of very small droplets usually produced and maintained with the aid of surfactants and having diameters of from 50 to 500 angstroms. Feb 07, 20 naproxen nap, figure 1 is a nonsteroidal antiinflammatory drug derived of propionic acid used widely as analgesic, antipyretic and for symptoms relief of dysmenorrheal pain. Hence administering glimepiride by oral route appears as a formidable challenge due to its poor absorption pattern and. Microemulsions microemulsions are thermodynamically stable, optically transparent, isotropic dispersions of aqueous and hydrocarbon liquids stabilized by an interfacial film.
Screening of safflower oil microemulsion for enhancing. At this position, i worked until 1209 2012 and was selected as professor of pharmaceutics in selection board held on 2808 2012 with effect from 19122010. Depending on the structure of the surfactant and the presence or absence of cosurfactant, an oilinwater system winsor type i, a waterinoil system. Different synthesis techniques have been developed to obtain highly pure monodomain barium ferrite particles for the application as permanent magnets. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Its low solubility leads to low dissolution rate and thus poor therapeutic efficacy. Physicalchemical characterisation, acta pharmaceutica hungarica 78 2008 1121 if. Nanoemulsion based1008 is a surfactantstabilized soybean oilinwater nanoemulsion adjuvant containing influenza antigen incorporated into the nanoemulsion by simple mixing. Cationic microemulsion polymerization of alkyl acrylates. Naproxen nap, figure 1 is a nonsteroidal antiinflammatory drug derived of propionic acid used widely as analgesic, antipyretic and for symptoms relief of dysmenorrheal pain.
A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. Soni, rekha mishra institute of pharmacy, bundelkhand university, jhansi, india. Thesis formulation and investigation of gelemulsions. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have a droplet size less than 100 nm.
A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of. This product provides three unique electron donor materials which produce a beneficial and sequential, stagedrelease of each individual electron donor component. Nanostructured microemulsion phase behavior using aot or. Ionic liquid microemulsion mediated in situ thermosynthesis of polyionic liquids and their adsorption properties for znii. Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. Mandal baroda college of pharmacy, vadodara, india. Department of pharmaceutics appasaheb birnale college of pharmacy, sangli 2. A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions surfactant concentration, salt content, temperature. It does not require an input of energy into the system to form. With the first approach, the development methodology becomes one of blending three components where one of the components is the emulsifier of interest, another is the continuous phase solvent, and the last component would be an evaluation of the need to include a coupling solvent. Schulman and coworker 1959 subsequently coined the term microemulsion. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. They described these systems as optically isotropic, transparent oil and water dispersions of droplets whose diameters were somewhat greater than swollen micelles. Ionic liquid microemulsionmediated in situ thermosynthesis of polyionic.
Nasal route for the delivery of some drugs offers an alternative in the pharmaceutical industry. Microemulsions microemulsions are thermodynamically stable, optically transparent, isotropic dispersions of aqueous and hydrocarbon liquids stabilized by an interfacial film of surfactant molecules microemulsions show diverse structural organizations due to wide range of surfactant concentrations, wateroil ratios, temperature etc. At this position, i worked until 1209 2012 and was selected as professor of pharmaceutics in selection board held on 2808 2012. However, the situation of petroleum industries in many countries needs much concern in improving the oil recovery technique. Tween 20, 40, 60, and 80 were used separately as surfactant with methanol, ethanol, 1. Design and characterization of microemulsion systems for naproxen. Microemulsions an introduction to properties and applications. The objective of the study was to optimize the proportion of different components for formulating oil in water microemulsion formulation meant for simultaneous transdermal delivery of. Iron magnetic nanoparticles were synthesized under an inert atmosphere via the reaction between fecl 3 and nabh 4 in droplets of water in a microemulsion consisting of octane with cetyl trimethylammonium bromide and butanol as surfactants. Nonsmall cell lung carcinoma nsclc, accounting for 80% of all lung cancers, is a lethal lung disorder because of uncontrollable tumor cell growth and consequent metastasis, invasion of. Microemulsion polymerization is a complex heterogeneous process where transport of monomers, free radicals and other species such as chain transfer agent, cosurfactant and inhibitors between the.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. With the first approach, the development methodology becomes one of blending three components where one of the components is the emulsifier of interest, another is the continuous phase solvent. Macroemulsions comprise large droplets and thus are unstable in the sense that the droplets. Pdf on mar 16, 2012, anna zielinskajurek and others published nanoparticles preparation using microemulsion systems find, read and cite all the research you need on researchgate.
Progress in microemulsion characterization sciencedirect. The microemulsion concept was introduced as early as 1940s by hoar and schulman who generated a clear singlephase solution by titrating a milky emulsion with hexanol. Different synthesis techniques have been developed to obtain highly. A thin fe 3 o 4 layer was produced on the iron nanoparticles using slow, controlled oxidation at room temperature.
Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a. A microemulsion preparation of nanoparticles of europium in. Formulation and evaluation of microemulsion based hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug.
Nanostructured microemulsion phase behavior using aot or extended surfactant combined with a cationic hydrotrope 54 ene oxide sulfate is also indicated. Microemulsion article about microemulsion by the free. Microemulsion polymerization is a complex heterogeneous process where transport of monomers, free radicals and other species such as chain transfer agent, cosurfactant and inhibitors between the aqueous and organic phases, takes place. The main potentialities of resveratrol for drug delivery systems. Screening of safflower oil microemulsion for enhancing bioavailability of lovastatin sujit arun desai1rishikesh ajit mohite,2, ashok a.
The aqueous phase may contain salts andor other ingredients, and. A comparative study of nonlipid nanoemulsion of propofol. Nonsmall cell lung carcinoma nsclc, accounting for 80% of all lung cancers, is a lethal lung disorder because of uncontrollable tumor cell growth and consequent metastasis, invasion of adjacent tissue, and loss of lung function. The aqueous phase may contain salts andor other ingredients, and the oil may actually be a complex mixture of different hydrocarbons and. Characterization of microemulsions prepared using isopropyl.
Dec 28, 2015 microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Microemulsionbased synergistic dualdrug codelivery system. To investigate the effect of various surfactants and cosurfactants, and their ratio on microemulsions prepared with isopropyl palmitate ipp methods. The aim of the present research work was to formulate hydrogel thickened microemulsion with good stability, powerful permeation ability and suitable viscosity for the topical menthol as oily phase, solvent for the lornoxicam, power. Microemulsion transdermal formulation for simultaneous. Microemulsion definition is an emulsion in which the dispersed phase is in the form of very small droplets usually produced and maintained with the aid of surfactants and having diameters of from 50. The microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. Abstract nanoemulsion ne is defined as an ow or wo emulsion producing a transparent product that has a droplet size from 20200nm and does not have the tendency to coalesce. Microemulsion synthesis of iron coreiron oxide shell. This poor solubility may cause poor dissolution and unpredicted bioavailability kiran et al.
A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions surfactant concentration, salt content. Microemulsion definition of microemulsion by merriamwebster. In contrast to a simple emulsion formed under shear, a microemulsion is a minimum energy state. Microemulsion method for synthesis of magnetic oxide nanoparticles by a. Pdf nanoparticles preparation using microemulsion systems. The trend of growing interest in alternative source of energy focuses on renewable products worldwide. Microemulsion method for synthesis of magnetic oxide. In some respects, microemulsions can be considered as smallscale. The term microemulsion first entered the scientific vernacular in 1959, through the work of jack h. Isbn 9789535102472, pdf isbn 9789535149712, published 2012 0316. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant. This product provides three unique electron donor materials which produce a. This chapter gives the details of experimental work done. The aim of the present research work was to formulate hydrogel thickened microemulsion with good.
To investigate the effect of various surfactants and cosurfactants, and their ratio on microemulsions prepared with isopropyl. This poor solubility may cause poor dissolution and unpredicted. Basic aspects of microemulsion microemulsion are fluid. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. Pdf formulation and evaluation of microemulsionbased. Department of quality assurance bharati vidyapeeth college of pharmacy, kolhapur. Preparation and characterization of functional compounds. Macroemulsions comprise large droplets and thus are unstable in the sense that the droplets sediment or float, depending on the densities of the dispersed phase and dispersion medium. Emulsion in which the particles of the dispersed phase have diameters from approximately 1 to 100. Recent asian journal of pharmaceutical sciences articles. To disperse two immiscible liquids, one needs a third component, namely, the emulsi.
First isolated from the roots of white hellebore veratrum glandiflorum, the extract of which contains transrsv of a purity range of 10% to 99%, rsv is mainly found in daily foods, such as grapes fresh grape skin contains about 50100 g of rsv, red wine 1. Formulation and evaluation of microemulsion based topical. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can. Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its ability to reduce interfacial tension between. Issa katime, jesus arellano, eduardo mendizabal, jorge flores subject.
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